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Sleeping tablets leave you disoriented? This can work as a warning



Japanese scientists have shown that a new sleeping pills class that keeps the awakening capability in response to the threat, unlike the usual prescribed medications that dampen the "intruder alert" for brain sleep.

Even during sleep, the brain is constantly processing sensory information and wakes us up if it detects a threat. However, the most commonly prescribed sleeping pad class, known as benzodiazepines, makes us less likely to wake up in response to sensory intake.

Discoveries have shown that the millions prescribed on these sleeping pills could sleep through a fire alarm as someone who sucks beside their bed.

However, the new class of drugs called dual-receptor antagonists (DORAs) is more selective in brain sleep or waking paths, which gives them advantages over benzodiazepines, researchers from the Kagoshima University said.

This includes a reduced "sleepwalking effect", which is less likely to affect DORA's ability to drive one day after use.

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"Benzodiazepines stimulate a widespread brain GABA-A receptor that sleeps, but also suppresses areas beyond the targeted brain – including" guards "who decide which sensory inputs should be processed," said author Tomoyuki Kuwaki, a professor at the University.

In the study, published in Frontiers in Behavioral Neuroscience, mice who received a new experimental hypothalamic remedy DORA-22 woke up so quickly when they were endangered as drug-free powders – and then dropped as fast as those who received standard tablets for sleep when the threat disappears.

While DORA-22 allows mice to wake up with a threat, it still helps them to sleep.

That way, DORA's selectivity could make a safer alternative to sleep – allowing a sensible brainwasher to remain cautious of threats, researchers say.

However, more research is needed on people to assure the safety and efficacy of DORA.

"Although it remains to be seen whether DORAs have the same properties when used in humans, our study provides an important and promising insight into the safety of these hypnotics," Kuwaki said.


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