Died by Sydney Brenner, a biologist who was awarded the Nobel Prize, helped to decipher the genetic code and whose research on the round waves caused a new area of human disease research. He was 92 years old.
The Salk Institute for Biological Studies in California, where Brenner spent part of his seven-decade career, said he died on Friday in Singapore.
"He will remember forever for his brilliant discoveries that have introduced a new era of science and a new generation of scientists," said Ronald Evans, a biologist at the institute.
In 2002, Brenner shared the Nobel Prize for Medicine for his contribution to discovering how genes control the cell division.
He and his two colleagues, John Sulston and Robert Horvitz, followed a transparent round worm known as C. elegans to determine how the cells share and create something new.
Findings about programmed cell death were key to understanding cancer development and laid the foundation for creating C. elegans as the main model of the organism in research.
His most important contribution to science, however, was the work he did with Francis Crick, the DNA finder, and others to determine the genetic code.
In 1961, DNA showed that DNA consists of a series of three nucleotides called codons that encode amino acids that make up the protein.
He also helped detect the messenger RNA, a molecule that directs the production of amino acids in the cell.
Born in 1927 in South Africa, Brenner spent most of his career in Britain and had a doctorate at Oxford University.
Later he joined the Cambridge University and shared office with Crick for 20 years.
At the beginning of the 1990s, Brenner went to California where he first worked at the Scripps Research Institute in La Jolli, and later joined Cricku as a distinguished professor at the Salk Institute.
The last part of his career was spent in building biomedical sciences in Singapore, where he became his first honorary citizen.
Brenner survived three children. His wife died in 2010.
© Nine Digital Pty Ltd 2019