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How 26-year-old Nadine deals with multiple sclerosis – News Science: Medicine and Psychology



In fact, Nadine Spuhler *, 26, just wanted to go shopping for a while, and then hang out with a boyfriend – but then everything changed. "Suddenly I did not feel my right half of the body," says a young woman. "And I did not get the money out of my shopping bag."

During the evening, it was not better, on the contrary: "I could not stand nor walk, my friend had to take me to the emergency hospital of the nearest hospital." .

It is also called multiple sclerosis as "a thousand-faced illness".

In November 2016, diagnosis was confirmed: multiple sclerosis (MS). It is a chronic inflammatory disease of the central nervous system, ie the Mozg and the spinal cord, which affects mostly young adults. The triggers are inflammatory medullary nerve fibers. These lesions or lesions cause the messages to pass away properly from the muscles, organs or other parts of the body to the brain – or vice versa.

Symptoms may vary widely depending on where the changes occur, from vision and mood disorders to muscle and drowsiness paralysis. Therefore, MS also calls "a thousand-faced illness".

Early diagnosis is important

This complicates the diagnosis, as in the case of Nadine Spuhler, especially because multiple symptoms often occur in other diseases. In addition, signs can be drawn at all stages of the disease or even remain a one-time event.

"Safety in the diagnosis is first given by various neurological tests and the MR, which displays the central nervous system," explains Jens Kuhle, neurologist and head of the MS Center of the Basel University Hospital. There are other diagnostic procedures such as cerebrospinal fluid, cerebrospinal fluid review.

"Many patients with MS have normal life years after the onset of the disease."Jens Kuhle, neurologist

"Early diagnosis is important in every case, because drug therapy can have a beneficial effect on the course of the disease in most cases or is completely stopped," says an expert. But when doctors visit is inevitable? "If neurological disorders such as vision problems, numbness of the extremities, weakness in the stomach and disappear within 24 hours occur, contact a family physician or a neurologist. If necessary, refer the patient to a specialized center."

Fear of the stroller

Nadine Spuhler's diagnosis was a shock. How long could she still practice her profession as a physiotherapist? Can they have children? "I thought I would inevitably have to spend my life in a wheelchair soon." In fact, this idea still exists, but: "This is definitely not the case," says Jens Kuhle. "Many people with MS who have medications now available to work very well and make the disease relatively mild – many MS patients can still walk years and decades after the onset of illness and live a normal life."

MS is still not curable. Although 25 years ago there were almost all available therapies, there are now about 15 remedies for a recovering illness. Meanwhile, the first drug was approved for people with primary progressive MS, shortened PPMS. For this form of MS, in which neurological deficits and physical disability increase slowly and without a relapse – there were no specific drugs. With ocrelizumab, patients now have access to the proven drug.

How does the drug work? Multiple sclerosis is one of the so-called autoimmune diseases. In doing so, their own defense mechanisms of the body instead of substances that are foreign to the body are falsely directed against their own tissue. In MS, certain cells fall into the brain and spinal cord and destroy the nervous tissue there. This may lead to the symptoms described above.

According to recent research, a certain group of immune cells, B cells, play an important role. New drugs with MS may attack these cells. The so-called monoclonal antibodies, such as ocrelizumab, can specifically intervene in the disease process in this way. "They recognize B cells in the blood and destroy them," explains Jens Kuhle. "So the number of lesions, ie brain damage, can be reduced and progression of the disease can be slowed down."

So I can temporarily forget the disease.Nadine Spuhler *, hit

A few weeks after the first hard hit Nadine Spuhler suffered two more. She first copied her doctor's pills, and from March 2018 she received new approved monoclonal antibodies. They are administered by infusion at intervals of six months. For Nadine Spuhler, they have a lasting effect: from the beginning of the therapy, there was no complaint about the MS.

"If I had to take pills a day, the disease would be present all the time, but sometimes I can forget it," she says, "because it has not been possible to have side effects such as upper respiratory tract infections since the beginning of therapy. makes me safe. "

* Editor changes name

(Swiss Family)

Created: 31.01.2019, 20:16 clock


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