Wednesday , February 24 2021

Dipped stem cells in the brain of the patient



Japanese researchers have injected the so-called. "IPS" stem cells in the brain of a patient with Parkinson's disease. This clinical trial aims to examine whether these cells can regenerate dopamine neurons and mitigate the symptoms.

Tim teamUniversity of Kyoto injected 2.4 million pluripotent cells, capable of giving any type of cell in the left brain, during the last three months of surgery last month. A man of fifties was well tolerated and will now be under the supervision of two years, said the University of Kyoto.

If there is no problem in the next six months, researchers will then add an additional 2.4 million cells, this time in the right part of the patient's brain. It is expected that these iPS cells from healthy donors will grow neurons dopamine producers, neurotransmitters involved in engine control.

In July, Kyoto University announced the holding of this clinical trial with seven participants aged between 50 and 69 years. "I greet patients for their courageous and determined participation", commented Professor Jun Takahashi, who announced the public television channel NHK on Friday.

Pluripotent cells to generate new neurons

Parkinson's disease is marked by the degeneration of dopamine neurons and results symptoms which are progressively aggravated, such as jitter, limb stiffness, and body movement decrease. This affects more than ten million people around the world, according to Parkinson's disease USA. Therapies are currently available "Improve the symptoms without slowing the progression of the disease"explains the foundation.

This test follows a test performed on a monkey s stem cells human origin that improved the ability to run receive suffer from Parkinson's disease, according to a study released at the end of August 2017 in a scientific journal nature, Survival of inserted cells, injection into the brain of the primate, was observed over two years, no br tumor.

induced pluripotent stem cells (iPS for induced pluripotent stem cells), adult cells are brought back to near embryonic condition by expressing them four genes (usually inactive in adult cells). This genetic manipulation gives them the ability to produce any kind cell (pluripotency), according to the body where they were transplanted. The use of iPS cells does not represent basic ethical problems, unlike received stem cells embryos People.

What to remember

  • Scientists from Kyoto University injected 2.4 million pluripotent cells into the brain of a patient.
  • These cells from healthy donors will need to regenerate dopamine neurons.
  • Overall, clinical examination should include seven patients.

Parkinson's Disease: Stem cells eliminate apes in apes

Article from Tokyo – AFP released on February 25, 2012

Monkeys that develop equivalents Parkinson's disease showed improvement in their symptoms after injecting into human stem cells. Technique can be tested in people since 2015.

Monkeys suffering from Parkinson's disease have achieved significant advances after implantation of human stem cells in the brain, Japanese researchers reported on Wednesday.

Four monkeys whose limbs were cramped (a common symptom syndrome from ParkinsonThose who fought for control over their bodies showed signs of improvement three months after the operation, said Jun Takahashi, a professor atUniversity of Kyoto, one of the authors of the study published in Journal of Parkinson's Disease.

Six months later transplantationFour tested primates could walk back to their cage, he added.

June Takahashi stated that at the time of implementation, 35% of stem cells were dopaminergic neurons, and about one-tenth of them were still alive a year later. To improve the effectiveness of treatment, he would like to increase the survival rate to 70%. He hopes to be able to carry out this experiment on humans by 2015. " We must first increase the number of dopaminergic neurons in instill, to reduce the risk of tumor " postoperative, he explained.

Pluripotent stem cells induced by humans

In this monkey experiment, Jun Takahashi and his team were used embryonic stem cellsbut in the case of medical experience scientists think they are using induced pluripotent stem cells (IPSC), created by incorporating four types of gene into human skin cells for reprogramming. These induced iPSCs thus generated back almost to the embryonic stage (undifferentiated).

Using embryonic stem cells, which many scientists consider to be very promising, contradicts. Religious groups believe that the culture of these cells is unethical, emphasizing it destruction of embryosIn Japan, however, nothing prohibits the use of these stations for scientific research.

Parkinson's disease is one of the main ones neurodegenerative diseasesafter Alzheimer's diseaseThis is also one of the most common causes of motor disability after accident cerebrovascular diseases.

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