The Oswaldo Cruz Foundation (Fiocruz) sent a letter to the Federal Public Ministry (MPF) on Tuesday (19th) informing it that the delivery of the Oxford vaccine against Covid-19 it will be postponed from February to March. VSee the postponement note below.
According to the agency, the reason for the delay in vaccine production in Brazil is that it did not receive one of the data for the production of Oxford / AstraZeneca vaccines.
Missing compound to start production is the active pharmaceutical ingredient (IFA) for which AstraZeneca is responsible.
The data comes from China and still does not have an arrival date, according to a note released by Fiocruz. Also according to the Foundation, receiving the ingredient was scheduled for January. Production details will be notified when the product arrival date is confirmed.
It’s an expectation deliver 100 million doses by July and another 110 million by the end of the year.
Bhutan calls for negotiations with China
The director of the Butantan Institute, Dimas Covas, requested that President Jair Bolsonaro (no party) have the dignity to defend the CoronaVac vaccine.
CoronaVac has developed the institute, which is affiliated with the government of Sao Paulo, in partnership with the Chinese laboratory Sinovac. Doses of the vaccine began to be administered on Sunday (17), shortly after the National Health Surveillance Agency (Anvisa) approved its emergency use.
He also called for Itamaraty’s agility to allow raw materials to come from China to continue production of anti-Covid-19 immunizers – the only one so far applied to the country’s population.
The statement was made this morning (19) at an event in the interior of São Paulo.
According to journalist Andréie Sadi’s blog, Bolsonar’s advisers are evaluating the names to bridge China with inputs for CoronaVac.
According to the blog, Vice President Hamilton Mourão said he is available to contact China and help with investments because he has a good relationship with the Chinese Vice President.
Fiocruz’s note on Oxford:
“Although still under contract in January, non-confirmation by today’s date of dispatch of the active pharmaceutical ingredient (IFA) may affect the production schedule originally scheduled for the release of the first batches between February 8 and 12. Production will be detailed as soon as confirmed Although adjustments are needed at the start of the originally agreed production schedule, Fiocruz continues its commitment to deliver 50 million doses by April this year, 100.4 million by July and another 110 million during the second half, a total of 210.4 million vaccines. in 2021. “
Step by step vaccine production:
- As raw material in hand, launched, then the actual processing of the vaccine. The first step is to carry out the formulation, when components are added to the vaccine concentrate that will stabilize the vaccine and dilute the virus concentration;
- Then, during charging the immunizer is transported from large containers stainless steel for small glass bottles, the same ones that will later go to health stations;
- Already with the immunizer these vials are closed rubber stopper and continue to the seam, where they get an aluminum seal;
- The last step consists of labeling and packaging, where the vials are marked with vaccine identification, batch number, date of manufacture and expiration date, and other important information. They are housed in boxes called cartridges that guarantee the protection of the packaging during distribution. At that moment some samples are separated and followed for strict quality control, where they will be subjected to tests of strength, stability and sterility.
Final medical record
To start distributing the vaccine in the country, it will be necessary to have a final health registration for use in Brazil.
According to Fiocruz, the forecast is that a meeting with Anvis is scheduled for this week.
Emergency vaccines generate expectations on the streets
The vaccines that began distribution on Monday (18) are CoronaVac, which he developed Chinese Laboratory Sinovac in partnership with Instituto Butantan, from Sao Paulo. The first doses came ready from China.
Butantan says it has produced another four million doses in Brazil. The federal government states that the Institute has not yet requested urgent approval for the use of these plots.
On Sunday (17th), the National Health Surveillance Agency (Anvisa) approved two vaccines.
Coronavac was 50% (50.38%) effective in the tests. This means that the vaccine developed by the Sinovac laboratory, in partnership with the Butantan Institute, halved the chances of catching Covid-19 and was 100% effective against severe symptoms.
- Understand how doses go from Bhutan and Fiocruz to healthcare facilities in Brazil
- Can I get coronavirus when I get the vaccine?
The vaccine, developed by the University of Oxford, the United Kingdom and the AstraZeneca laboratory, had an average efficacy of 70% (70.4%). Oxford and Coronavac must be administered in two doses, 28 days apart.
The two vaccines also need to be stored in refrigerators at temperatures of 2 to 8 ° C.