Sleep wake disorder is a well-recognized Alzheimer's symptom, but recent studies have shown that an unorganized biological clock can also be a key driver of neurodegenerative disease.
Research on the role of circadian rhythms in the development of Alzheimer's and other forms of dementia is among the findings of the findings that will be presented this week at Neuroscience 2018, the annual meeting of the Society for Neuroscience, which is being conducted at the San Diegu Convention Center.
On Monday morning, Brian Lananna, University of Washington at St. Louis explorers, presented preliminary results that show how hitting the mute button at circadian rhythms at the cellular level can damage neurons, brain cells responsible for human knowledge.
Working in Petri dishes and mice, researchers have disrupted the genes in astrocytes, star cells that support neurons, causing them to stop producing the key protein that, after drying, has led to inflammation of the inflammation.
These findings point to the intriguing question: Does remarkable circadian rhythm cause Alzheimer's disease?
Lananna probably said. There are many other patterns in the game that many assumptions included the accumulation of other proteins that, over time, result in scattered levels of memory loss.
But it is possible, Lananna said, that a disturbed biological clock accelerates the process that is already underway.
"There is a lot of suggestive evidence, although it's not final, that inflammation may be a driver in Alzheimer's disease," Lananna said. "It is possible that if someone is already starting to develop Alzheimer's, this increase in inflammation through things like a circadian disorder can be pushing people over the edge or accelerating progression."
Further testing will be more closely concerned with key protein levels in Alzheimer's patients, comparing results with those who do not have the disease. Finally, deeper study could lead to remedies that could be used to compensate when circadian rhythms are not synchronized.
The findings are based on the growing number of evidence that there are serious consequences for disturbing circadian rhythms. Other studies have linked biological clock cracking with a range of health effects of heart disease to premature death.
Although this science is still developing, researchers have increasingly advised the public that getting enough sleep, in synchronization with normal dark-dark patterns present in nature, is likely to have a protective effect.
One of the major moves in the last few years is limiting the time of late-night exposure, which some studies have shown may interfere with normal sleep patterns.
Sleep quality is still an area of research continuation.
Deep sleep generally proved to be the most useful type of sleep, and several papers on Neuroscience 2018 supported that notion.
The Walter Reed Army Institute of Research studied soldiers who had a brain tumor, finding that this type of trauma is associated with a significant reduction in the deep sleep each participant gets each night. Study Walter Reed had previously constructed soldiers with 40 hours of sleep attenuation to determine if their effect was compromised or not.
Such a long stretch without sleep, said Cpt. Allison Brager, Walter Reed's researcher, was designed to simulate contemporary warfare when many soldiers have to work in the dark, and missions can last for more than 24 hours.
"We are really proud of having a night, and the consequences of having a night are that you'll be asleep and move the sleep rhythm to have your upper arm," Brager said.
Research findings have shown that soldiers who had recently had brain paralysis were about 100 milliseconds slower after 40 hours of sleep deprivation than those who were not conundated. Although less than a second of the difference in reaction times might not look much to civilians, Brager, who said he was speaking alone, not the US military, said the time of critical decision-making in the fight.
"Under the fire, that may be the difference between life or death," Brager said.
The lack of deep sleep has also been shown to affect emotional regulation, according to findings presented by Eti Ben Simon of the Center for Human Dream of Science at UC Berkeley.
The researchers investigated 18 healthy participants who were evaluated before and after eight o'clock in the evening, where half slept and half slept. For those without a deep sleep, anxiety has increased significantly, and brain imaging has shown greater activity in the emotional areas of the brain and also in the "frontal" areas that normally suppress anxiety.
Getting a full eight hours of sleep every night, it seems, is a good anti-anxiety medicine.
"If we are chronically sleepy and you lose sleep, it could feel a higher level of anxiety and the development of anxiety disorder," said Ben Simon.