When the heart is formed, its muscular cells have very limited regeneration ability. After a heart attack, these cells quench and form scarring tissue, which potentially leads people to heart failure. The new study reveals the possibility of using microRNA – small molecules that regulate gene function – for regeneration of cardiac muscle. In mice, two heart-rich microRNAs, miR-19a and miR-19b, improved cardiac muscle and improved cardiac function after a heart attack.
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