Cristiano Ronaldo finished his San Siro hoodoo to help Juventus win 2-0 after AC Milan forward Gonzalo Higuain missed a penalty against his former team on Sunday.
Higuain left Juventus in the upcoming season after signing Ronaldo and had a nightmare because he was also dismissed for seven minutes after disagreement after being booked for a foul on Medhi Benatia.
Mario Mandžukić scored early and Ronaldo was sealed nine minutes late, while Serie A leaders defeated Milan in returning his sixth-time advantage over second-placed Napoli who beat Genoa 2-1 on Saturday.
It was Ronaldo's first goal in six games in San Siro, which previously played at the iconic stadium for Manchester United and Real Madrid.
The Portuguese advanced to the flag of the corner, inviting all his teammates to celebrate with him.
"I'm very happy, especially for the team," Ronaldo said. "We played good football, it was never easy to play in San Siro against Milan.
"We have shown that we are superior, I am very happy, it is important victory, we have returned six points ahead of Naples, and achieved the goal, I am satisfied."
Milan turned to fifth, more precisely behind Lazio, the fourth, after finishing the win in three leagues.
"We have played against a team that has been winning for years and who is signed every year by the top player," coach Milan Gennaro Gattuso said. "Our differences are different, maybe the punishment could change something, but I loved the team, not everything was thrown away.
"Juventus is not only the strongest team in Italy but it has been built in Europe with Manchester City and Barcelona. Maybe we stayed in the game all the time … but I never had the feeling that we were going to hurt them."
Juventus was trying to move from Wednesday to a 2-1 home defeat at Manchester United and greeted Mandzukic from injury.
Croatia should have started in less than eight minutes to break the deadlock and headed to the back of the head on Alexa Sandro's cross on the left.
There were several clear opportunities in the cage, but Milan was sentenced shortly before the half-time when Benatia blocked Higuain's effort by hand.
The Higuain player who had to be helped off the pitch, was Juventus Wojciech Szczesny as he was unable to finish the game.
Juventus doubled their time for nine minutes. Joao Cancelo hit Milan's goalkeeper Gianluigi Donnarumma, but only on the Ronalda track, which collapsed on the nearby roof.
In other results Atalanta scored Inter 4-1, Roma beat Sampdoria 4-1, Chievo Verona took 2-2 with Bologna, Lazio earned far from 1-1 in Sassuolou while Empoli beat Udinese 2-1.