The woman is dead after being hit in the head between two vehicles at the main intersection at Clarenville.
The RCMP said the other person was taken to a hospital with injuries but did not explain whether they were less serious or serious.
The Drive Drive and Manitoba Drive intersection is closed after 12 hours.
The road has since opened again.
On the scene, he was an analyst for traffic accidents and the investigation is in progress since Thursday afternoon.
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