The CIC bioGUNE leads RedHYPOX, a thematic network of research excellence in hypoxia by ten research groups, with a common interest in studying the various mechanisms that mediate hypoxia (oxygen deficiency) reactions and its relevance in physiological and pathological conditions.
BILBAO. According to CIC bioGUNE, research on cellular and molecular basis of hypoxic response is a subject of great interest in biomedicine. "The challenge is there, and expectations are very ambitious from a basic and applied point of view, as research fruits can provide new opportunities for understanding and improving the diagnosis and treatment of diseases that are endemic to our society," said Dr Edurne Berra, Network Coordinator responsible for HypoxiPATH group CIC bioGUNE.
Two days, Granada meets research staff of the Thematic Research Network of Excellence in Hypoxia, an initiative funded by the Ministry of Science, Innovation and Universities. The meeting was attended by experts, international referents in their fields, in different areas of knowledge.
RedHYPOX brings together a number of experimental approaches, from computer access to clinical research, through a wide range of cell and animal models, as explained by the Research Center
RedHYPOX members belong to a wide range of institutions that have "solid records" in fundamental and translational research, including several universities (Autonomous University of Madrid, Complutense University in Madrid and the University of Seville), hospitals (Hebron dormitory and Hospital de la Princesa) and research centers (CIC bioGUNE, IBiS and IBSAL).
CIC bioGUNE has shown that oxygen is vital, and most cells are "dependent" on oxygen. This is so that his deficit (or hypoxia), even transient, can have dramatic consequences. Therefore, organisms have mechanisms that have enabled different levels to react, adapt and guarantee oxygen homeostasis.
"Hypoxic" episodes occur during embryonic development and in healthy adults, for example, during height acclimatization, wound healing, or physical exercise. Moreover, the use of more or less sophisticated hypoxic equipment to improve sports performance is relatively common.
But inadequate oxygen supply (excess or deficiency) is also associated with diseases such as cancer, metabolic (for example, diabetes), inflammatory (for example, Crohn's disease), neurodegenerative (Alzheimer's and Parkinson's disease) or ischemic diseases (for example, stroke and stroke).