Tuesday , May 18 2021

Encas bacteria involved in Alzheimer's disease?



Researchers cite new findings on how bactors involved in gum disease can travel all over the body, secreting toxins associated with Alzheimer's disease, rheumatoid arthritis and pneumonia aspiration. They found evidence of bacteria in brain patterns of people with Alzheimer's disease and used mice to show that bacteria could find the way from mouth to brain.

bacteriaPorphyromonas gingivalis & quot;is a harmful substance involved in periodontitis, the most severe form of gum disease. These new findings emphasize the importance good tooth hygiene since scientists are looking for ways to better control this common bacterial infection.

"Oral hygiene is very important during our lives, Not only do you have a nice smile than i reduce the risk of many serious illnessesJan Potempa, professor at the Louisville University School of Dental Medicine and Director of the Department of Microbiology at Jagiellonian University in Krakow, Poland. Alzheimer's disease they must be extremely concerned about the prevention of gum diseasehe adds.

Although previous researchers discovered the presence of & P; Geminalis in brain samples of patients with Alzheimer's disease, the Potempa team, in collaboration with Cortexme, Inc., provides solid evidence that bacteria may contribute to the development of Alzheimer's disease. Potempa is an exploration at the annual meeting of the American Association of Anatomists, held at the Experimental Biology Meeting in Orlando, Florida, USA.

The researchers compared brain patterns to deceased people with and without Alzheimer's disease When they died, they were about the same age. They found that & # 39; P. Gingivalis was more common in Alzheimer's patients, as evidenced by the DNA imprint of bacteria and the presence of its key toxins, known as gingipaine.

Ability to block bacterial migration

In mice studies, they showed that & quot; P. Gingival can move from the mouth to the brain and this migration can be blocked by gingipain chemicals. An experimental drug that blocks gingipain, known as COR388, is currently undergoing clinical trials 1 for Alzheimer's disease. Cortexyme, Inc. and the Potempa team are working on other compounds that block important & # 39; P & # 39; enzymes. Gingival and other gum bacteria with the hope that they will undermine their role in the progression of Alzheimer's and other diseases.

Researchers also report on the role of bacteria in rheumatoid arthritis of autoimmune diseases, as well as aspiration pneumonia, pulmonary infection caused by inhalation of food or saliva. "Main Toxins & amp; P; gingivalis, the enzymes that bacteria need to carry out their diabolical tasks are good targets for possible new medical interventions to suppress various diseases – says Potempa. The beauty of these approaches to antibiotics is that these interventions are directed only to key pathogens, leaving good bacteria and guests, what do we need? "

"P. Gingivalis usually begins infiltrate into the right during adolescence. Approximately one in five people under the age of 30 has a low level of bacteria in the gums. Although it is not harmful to most people, if grown in large quantities, bacteria cause the formation of an immune system of the body inflammationwhat creates redness. swellingbleeding and erosion of gum tissue.

If things are worse, P. Gingivalis even does benign bacteria in the mouth change their activity and increase even more immune response. Bacteria can travel from the mouth to the bloodstream through a simple act of chewing or brushing the teeth.

The best way to avoid this is & # 39; P. Gingivalis comes out of control brushing teeth and dental flossing regularly and visit the dental hygienist at least once a year, advises Potempa. Smokers and the elderly have a higher risk of infection. It is also believed that genetic factors play a role, but are still not well understood.


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