Saturday , May 15 2021

IBiS-Virgen del Rocío reveals a new round that leads to increased growth and malignancy of colon cancer


A team of researchers from the Institute of Biomedicine Sevilla -IBiS, located at the University Hospital of Virgen del Rocío, has discovered a new circuit that leads to increased tumor growth and malignancy. The work, which combines tumor cell line studies, animal models and databases of patients treated at the Seville hospital, was recently published in the journal Nature Publishing Group's Oncogene journal.

The results are of great importance for the knowledge of tumor biology and the determination of their evolution. In addition, the PLD2 protein in which the studies are targeted may serve as a therapeutic target for the treatment of colon cancer and potentially other types of tumors.

Thus, they described the microorganism in which the tumor is present, and in which the protein that tumors tumor cells in the colon cancer causes changes. Tumor microcirculation consists of tumor and non-tumor cells, among which there are many interactions that contribute to tumor development. To achieve this, they used tumor samples of patients treated at Virgen del Rocío University Hospital, which were provided through Biobank's Andalusian Public Health System.

Specifically, the research concludes that the protein phospholipase D2 (PLD2), expressed at abnormally high levels in patients with colon cancer, excludes tumor cells and changes the non-tumor cells of the microcirculation causing them. a situation that experts call "aging".

Breast cancer consists of stopping the cell division of the cells that are suffering from it, despite being able to excrete a number of factors that increase tumor cell tumor capacity. This creates a circle between tumor and non-tumor cells, leading to an increase in the number of tumor stem cells, which have a higher proliferative capacity than normal tumor cells, similar to any other pluripotent stem cells.

The work was conducted by Dr. Sandra Muñoz Galván as the principal investigator and was led by Dr. Amancio Carnero, CSIC research scientist.


Colorectal cancer is the most common tumor in the population and the other cause of cancer death in men and women. Usually, the symptoms do not appear at an early stage, although it can be cured in 90 percent of the cases if detected early, which is achieved by a simple chair test, which points to the entire population between 50 and 69 years. Early detection of colon cancer and flat cancer of the Ministry of Health.

Experts on digestive disorders, led by Juan Manuel Bozad, are involved in consultations with suspected colon cancer patients who are subjected to colonoscopy or biopsy, preferably through the colon cancer process, in collaboration with the Radiodiagnostic Unit Professionals directed by Francis Javier Castella or Pathological Anatomy, coordinated by Enrique de Álava.

The most complicated cases were finally solved in the operating room and sent to the General Surgery Unit of the Virgen del Rocío University Hospital, led by Javier Padillo, who annually operates around 200 patients for colon cancer and about 80 for the rectum. For this they use minimally invasive techniques, robotic surgery and others more complex, according to the degree of pathology that the patient represents.

Source link