Thursday , May 6 2021

The genetic reason why some people do not suffer mamurluk after a drunken stupor



The end of the year and the health is multiplied. But after a few "beards of the beard" many of us ended up being so bored.

Severe headaches, anxious stomach, fatigue, and weakness are some of the symptoms that cause mumurluk.

However, this does not happen to everyone: some happy people will not suffer the next day if they go over drinks.

In fact, several studies suggest that up to 25% of those who drink excessively manage to avoid unpleasant consequences.

  • Months and years where you lose your life if you drink alcohol every day
  • Why do some people lose their memory during drunken stupor (and what does this tell us about their health)?

Ava Karuso is one of these people. This 25-year-old Australian says he can go to the bar with friends, drink them and be perfectly healthy the next day (but not her friends).

Ava wanted to know how it was possible and sent her query to the BBC radio program "Interesting Rutherford and Fry's cases", in which scientists Adam Rutherford and Hannah Fry explored the secrets of everyday life that he sent to the public. .

"Why do some people suffer so much after one night of drinking, and others (like me) do not even feel any effect?" The young Australian asked.

Brain with a glass of alcohol in front.

Alcohol affects the brain.

To find out, Rutherford and Fry started asking experts how alcohol affects our bodies.

"When you drink alcohol, it can take between 10 and 90 minutes to feel the effects, but in reality alcohol has a very rapid effect on blood flow," explained Sally Adams, a health psychologist from Bath University, England.

"(Alcohol) crosses the blood-brain barrier and basically communicates with all neurotransmitters in your brain," said an expert, one of the few scientists in the world who devoted himself to studying the nightmare.

Neurotransmitters are molecules that link our brain and nerve cells, and alcohol affects most of these transmissions.

"It explains why we experience the effects as rare as we can not talk or walk well," said Adams. We can not clearly think, and we usually act impulsively.

Liver

But the effects of alcohol on our brain have more to do with drinking. To better understand the mumurluk, we need to focus on another organ: the liver, which processes alcohol.

"When you drink alcohol, your body wants to eliminate it, because you have a liver enzyme called alcohol dehydrogenase," Andrea Sella from the University College in London said.

The enzyme removes hydrogen from the alcohol and transforms it into something called acetaldehyde.

"Acetaldehyde is very toxic," Sella said. Many experts believe that this is the main cause of the nightmare.

The figure of a man who drinks alcohol and reaches his liver

The liver is responsible for removing alcohol from your blood, but not for processing at the same rate.

But if we all handle alcohol, why only do some people feel the consequences of the nightmare?

Sella has explained that it is related to the amount of alcohol dehydrogenase enzyme we have in our liver.

"The rate at which the alcohol will be processed will depend on the amount of alcohol dehydrogenase you have in your system," he explained.

Genetic differences

This factor (the amount of enzymes that metabolize alcohol in the liver) determines your genetics.

"Different people have different amounts of alcoholic dehydrogenase," Sella explained.

"If you need to get rid of acetaldehyde and the levels of this compound are accumulating, you will feel very bad," he said.

That will probably be the key to answering Ava's question.

Maybe he's genetically better prepared for alcohol processing than his friends and it explains her tolerance.

A man with a mumur or a flu shot looking at the mirror.

Symptoms of mamurluka may look like flu.

But there are other possible explanations.

For example, this may be related to your immune system.

Inflammatory reaction

"It is not yet clear why people feel so bad during the nightmare, but the best theory is that this is an immune response," says Adam Rogers, author of the book "Evidence: Alcohol Science." .

Experts have found that excess alcohol creates an immune response that causes release of certain substances that cause inflammation, causing various symptoms.

"If you've ever had a bumblebee, you'll know that you feel like flu," Rogers said. "You just feel bad, as if you have an infection."

So, you know. If you have a drink for Christmas and New Year, your liver and the immune system are likely to take your toll.

Except, of course, you're like Ava.


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