Saturday , January 23 2021

Antibiotic resistance is widespread throughout Europe



Antimicrobial Resistance (AMR) has increased by 32% since 2007 in Europe, according to a new report.

The new Lancet report based on data provided by EARS-Net in 2015 is 33,000 deaths due to AMR, 39% of cases caused by antibiotic-resistant bacteria infections of the last lines such as carbapenems and colistins. According to estimates of the European Center for Disease Control and Prevention (ECDC) in 2007 there were 25,100 deaths related to AMR.

The authors of the study say that the burden of these infections is comparable to those in combination with flu, tuberculosis and HIV / AIDS, but that the contribution of antibiotic-resistant bacteria to the overall burden of large differences between countries. According to the study, 75% of the disease burden is caused by health-related infections (HAIs).

However, the problem does not seem to be limited to hospital infections. Researchers at the Julius Kühn Institute in Germany reported in mBIO that fruits and vegetables are a reservoir for portable gene for resistance to antibiotics that often avoid traditional molecular detection methods. These antibiotic resistance genes could avoid detection methods independent of cultivation such as PCR, but can still be transmitted to human pathogens or commensals.

The team mixed 24 samples of salads, roses and roots purchased at supermarkets in Germany to analyze portable gene for resistance to bacterial cultivation and DNA-based methods. Although initially low in abundance, TET-resistant E. coli were isolated from all purchased product samples after non-selective enrichment. TET-resistant E. coli isolates were mostly isolated from roots, followed by mixed salad and rucula ready to eat. They further demonstrated that multidrug resistance plasms were transferable to sensitive recipients of E. coli, a process that can occur in the human intestine.

Almost all E. coli isolates were resistant to antibiotics from at least one class and two isolates were resistant to eight classes; tetracyclines, penicillins, third generation cephalosporins, fluoroquinolones, aminoglycosides, sulfonamides, phenolic and trimethoprim. No real-time PCR (RT-PCR) systems are available that allow detection and quantification of these non-cultivating plasmids in the total DNA community.

Research has shown that fruit and vegetable-related bacteria can carry different plasmids that could represent an important link between the microbial environment and the human intestine. Researchers have said that such bacteria should be considered important through the spread of portable antibiotic resistance, which may be relevant for patients under antibiotics.

International efforts to combat the AMR, like the IMABLE ENABLE project, have increased this year. At a recent World Health Organization summit in Berlin, a 40-million-euro investment for CARB-X and EUR 50 million for GARPD was announced by German research minister Anja Karliczek. Field progress and the latest advances in AMR diagnostics and therapies will be highlighted by developers, policy makers, regulators and IP experts at the 12th Berlin Life Science Conference.


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