The scientists used spent bottles of Moderna vaccine to reverse engineer its mRNA sequences.
Scientists at Stanford University reverse engineered the mRNA sequence of Modern’s Covid-19 vaccine and published it on Github, a source-hosted website.
The motherboard was the first to report the story. Two Stanford scientists, Andrew Fire and Massa Shoura, reportedly collected depleted vaccine vials to break down mRNA sequences, a list of guidelines that tell the human body how to fight offensive viruses.
“With the release of the COVID-19 vaccine, these synthetic mRNAs have become widespread types of RNA in many human populations. Despite their ubiquity, sequences are not always available for such RNAs, ”says a post on GitHub, signed by eleven scientists.
“Sequence data sharing for widely used therapeutics has the advantage of allowing all researchers or clinicians using sequencing approaches to quickly identify such sequences as therapeutic rather than domestic or infectious in origin,” they said.
Similarly, on another occasion, scientists were able to deconstruct the Covid-19 sequence of Pfizer-BioNTech. They also made them public. Since Modern’s sequence was not publicly available, scientists from Stanford Shoura and Fire contacted the company to seek permission to share the code online. They did not hear from the company and continued posting it on GitHub.
Scientists who broke down mRNA in the Covid-19 vaccine say they experimented on spent vaccine vials at Stanford and Veteran’s Affairs vaccination sites after seeking permission from the Federal Drug Administration (FDA).
Although knowledge of the mRNA sequences of Covid-19 would not represent domestic versions, Fire and Shoura say the information could help “analyze future biomedical datasets.”
Stuart Turville, an associate professor of immunology and pathology at the Kirby Institute at the University of New South Wales, told The Guardian Australia that one should not try and attempt to make such a vaccine outside the scientific environment. If someone does that, he said, “It would be like baking an intricate cake with just knowing the basic ingredients.”
However, deconstructing the vaccine remains an important step in making information available to scientists, as the world struggles to make Covid-19 vaccine available to everyone.
Turville said it would be important to be able to determine the RNA created by the vaccine and the RNA from the virus, because molecular diagnostics can give false positive results if RNA like this is in large quantities.
“So it would be good to know the sequence, so if false positive results appear, you can solve the problem of whether the RNA vaccine is the source of your contamination.”
Source: TRT World