Image: Figure of α-sinuklein collagen microscope in addition (red) (Photo courtesy VARI).
A new study suggests that the normal human supplement contains pathogenic α-sinuklein forms, which affect the risk of Parkinson's disease (PD).
Researchers from the Van Andel Research Institute (VARI, Grand Rapids, MI, USA), the Center for Addiction and Mental Health (CAMH, Toronto, Canada) and other institutions conducted two independent epidemiological studies that analyzed data sets from the Swedish National Register of Patients to the ability of the additive to modify PD risk and influence pathogenesis was determined. The study encompassed 1,698,000 people who followed up to 52 years, for a total of nearly 92 million personal years.
The results showed that the risk of PD development was 19% lower among those who surgically removed their childhood supplement. Further analysis suggests that people who developed PD despite early life in appendectomy usually have symptoms appear 3.6 years later than similar in the age of the patients and that people living in rural areas benefit most. The researchers then examined tissue supplementation of 48 healthy people; In 46 of them, they found intraneuronal α-sinuklein aggregates and abundant a-synuclein truncation products known to accumulate in Lewy's bodies, the pathological sign of PD.
They also found that a healthy human blood-forming supplement contains human appendicitis lysates that caused rapid cleavage and oligomerization of full-length recombinant α-sinuklein. They therefore suggest that the normal human supplement inherently contains pathogenic α-sinuklein forms that may affect the risk of PD development and whether the supplement is on or not negligible. The study was published on October 31, 2018 in Science Translational Medicine.
"Our findings point to addiction as a place of origin for Parkinson's disease and provide a way ahead for designing new treatment strategies that affect the role of gastrointestinal tract in developing disease," said senior author Viviane Labrie, PhD, VARI. "While reputation is largely unnecessary, the supplement actually plays an important role in our immune system, regulating the makeup of our intestinal bacteria and now, as demonstrated by our work, in Parkinson's disease."
"We were surprised that the pathogenic forms of α-sinuklein were so widespread in the intake of people with or without Parkinson's disease, but these aggregates, although toxic to the brain, are quite normal when in contact. it can be the cause of the disease, "Dr. Labrie concluded. "Parkinson's disease is relatively rare, less than one percent of the population, and there must be some other mechanism or compilation of events that allow the addiction to affect Parkinson's dangers."
The attachment is a narrow, elongated, blind-extension extension of the large intestine projecting from the cecum, near the interstitial with the small intestine. Specifically known as a "veriform" supplement for red hollow form, the supplement is only present in humans, certain anthropoid apes, and Australian wombats. The appendix is quite well known despite its small size and opaque location, and because of its tendency to be easily infested with bacteria, leading to appendicitis and the function remains unclear.
Van Andel Research Institute
Center for Addiction and Mental Health