Opioid exposure to the uterus was associated with higher risks for short-term and long-term adverse consequences, including premature birth and non-smokers and physical health disorders in children.
This observational study analyzed clinical and epidemiological data for a group of 8,509 mothers and infants born at birth since 1998, and 3,153 children who continued to follow up to 21 years of age. Of the 8509 children, 454 (5.3%) had opioid exposure in the uterus, which was defined as the use of opioids in the mother or the clinical diagnosis of neonatal abstinence syndrome. The study reports that uterine opioid exposure is associated with a higher probability of being small for gestational age and premature labor.
Opioid exposure in uterus was also associated with postnatal neurorasive and physical disorders, including increased likelihood of diagnosis of behavioral disorders or emotional disorders as well as lack of normal physiological development in children older than 6 years and later and more likely. Attention Deficit / Hyperactivity Disorder. The limitations of the study to be considered include that mothers may have used other substances, such as alcohol, cigarettes, marijuana, and stimulants, which could have an impact on outcomes.