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Chinese scientists say they experiment with genetically modified children – "Pandora's Appeal Is Open" | page



A Chinese scientist says he is behind the creation of the first genetically modified child in the world. The result of the researcher He Jiankuis's most exquisite experiments came in and made a strong critique.

"I have to apologize for the unexpected leak of results. Clinical trials were suspended due to the current situation, Jiankui said today at the major international biomedical conference in Hong Kong.

Researcher He Jiankui is associated with the Department of Science and Technology of the University of Shenzhen.

Replace the bottom of the girl to remove HIV

Jiankui announced that he was able to experiment with DNA on the twins in an attempt to resist AIDS. Girls, born a few weeks ago, have a father who is HIV positive.

According to him, girls need such protection as there are no vaccines.

The task of the experiment was not confirmed by any independent body, and He Jiankui did not publish his findings in any scientific writing so other researchers could review the research results.

If Hes's story is true, this is the first time that such an intervention has been made.

Eight volunteers – HIV-positive fathers and HIV-negative mothers – initially reported an experiment, but the pair jumped at a later stage.

Wakes hopes that gene modification will prevent the disease

He Jiankui defends his experiment with the hope of preventing the disease by genetic modification.

He Jiankui is a humane experiment. University of Hong Kong 28.11.2018

He Jiankui is a humane experiment. University of Hong Kong 28.11.2018
He Jiankui is a humane experiment. University of Hong Kong 28.11.2018
Image: EPA-EFE / ALEX HOFFORD
DNA, genetics, genetics, fetal, baby, science, embryo, Genkarta, chromosome, experiment, Jiankui

Hes's speech in Hong Kong was his first official display of a controversial experiment with two girls.

At the same time he informed the public that there was a pregnant woman who was "potentially" involved in her experiment. It seems that pregnancy is at an early stage.

Their publication raises more questions than answers

Industry leaders said after Hes's speech in Hong Kong, which now looks at HP's experimentation with even greater suspicions and concerns and that Hes's lecture posed more questions than answers.

The conference failed to answer questions about who paid for their research and how to ensure that participants understood all the potential risks and benefits of the operation.

He could not explain why he kept his job at work when he was done.

Rhododendron can be inherited

Researchers warn of the consequences of genetic modification in human embryos.

Changing DNA before or during conception is highly controversial because modification can inherit, damage other genes, and affect the entire genome.

Genetic modification – with the exception of laboratory research – is forbidden in many countries.

Jennifer Doudna, a researcher at the California-Berkeley University, told the AP news agency that he was glad Jiankui came forward, but he felt that his experiment was unacceptable.

Doudna is one of the researchers who developed the CRISPR / Cas9 modification tool for which he claims to have used it for the experiment.

Jianku's experiment did not meet the criteria that require genetic engineering– Nobel laureates David Baltimore

Nobel Laureates and Conference Manager David Baltimore pointed out at the conference that Hes's job was irresponsible because he did not meet the criteria many researchers agreed a few years ago – the criteria to be met before considering reconsidering genetic modification.

According to him, it is irresponsible to continue with an experiment in which security aspects are not taken into account. It also criticizes the lack of transparency.

– The results are presented after everything has happened and the children are born.

embryo

embryo
Image: Brain Light / Alamy / All Over Press
Embryology, genetics, research, ethics

"I personally do not think this is just a medical one. There are other illnesses where the need for such surgery is much more urgent than the prevention of HIV infection.

According to Baltimore, this shows that the scientific community has obviously failed to control itself and prevent the early attempt to modify DNA.

George Daley, another researcher who attended a conference in Hong Kong, sent a warning to the participants. He pointed out that there is a risk of reacting to genetically modified research due to Hes's experiments – and that the research community can be expensive.

"Just because this first case may be a mistake, you should not stand your head in the sand and avoid thinking of very, very positive aspects that can lead to a more responsible way," Daley said.

The question is about security and ethics

The safety and ethics of this type of experiment raise concerns.

Many researchers strongly challenge the exposure of healthy embryos and babies to genetic modification.

– Pandora's box opened, written by over 100 researchers – mostly from China – with open script. They highlighted the danger and unjustified use of CRISPR / Cas9 technology to manipulate human embryo genes.

Chinese authorities and many research units have also abandoned trials.

It is not clear whether it has violated China's research laws and is in danger of being punished for its experimentation.

Sources: AP, AFP, Reuters


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