Researchers from the University of Washington have discovered a number of diseases and other health problems in the progeny of rats exposed to glyphosate, the most popular weed killer in the world. In the first study of this species, the researchers have seen descendants of exposed rats who have developed prostate, kidney and ovarian diseases, obesity and birth abnormalities.
Michael Skinner, a professor of biological sciences at WSU and colleagues, exhibited herbicide in pregnancy between the eighth and 14th day of pregnancy. The dose – half the amount expected to have no adverse effect – did not give any obvious adverse effects on either the parents or the first generation of progeny.
But write in the journal Scientific Reports, researchers say they saw a "dramatic increase" in several pathologies affecting the second and third generation. The second generation had "significant increases" in testicular, ovarian and lactic gastric diseases, as well as obesity. In men of the third generation, researchers have seen a 30 percent increase in prostate disease – three times more than the control population. The third generation of women had a 40 percent increase in kidney disease, or four times the control.
More than one-third of mothers of the second generation had unsuccessful pregnancies, most of whom were killed. Two out of five men and women in the third generation were overweight.
Skinner and his colleagues refer to this phenomenon as "generational toxicology" and have seen it over the years in fungicides, pesticides, jet fuel, Bisphenol A, DEET-rejecting insects and herbicide atrazine. At work there are epigenetic changes that involve and exclude the genes, often due to the influence of the environment.
Skinner said he decided to study glyphosate "because it is one of the most commonly used compounds in the world".
Chemistry has been the subject of numerous studies of its effects on health. Skinner's study is the third in recent months alone in Washington. The University of Washington study published in February revealed that chemicals increase the risk of non-Hodgkin's lymphoma by as much as 41 percent. The State University study in Washington published in December showed that residents of a country living near a herbicide-treated area one third more likely to die from early Parkinson's disease death.
Generic toxic chemistry represents a new disadvantage that Skinner and his colleagues say that they should be involved in risk assessment.
"The ability of glyphosates and other toxic substances in the environment to affect our future generations needs to be considered," they write, "and is potentially as important as the direct exposure to toxicology that is currently being done to assess the risk."
Researchers see a popular herbicide that affects health through generations
Deepika Kubsad et al., Evaluation of epigenic transgenic inheritance of pathology and epimutation of semen of glyphosate: generic toxicology, Scientific Reports (2019). DOI: 10,1038 / s41598-019-42860-0
Researchers see effects on health during the generation of the popular weed killer (2019, April 23)
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