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Hint: how to increase the density of the androgen receptor



See if this describes you …

Lift up hard and heavy. Make sure you get 1.6 grams of protein per kilogram of body weight every day and even keep a food record. Articles and new studies are poured out. Use the right supplements. Hell, you've even added the demand for more muscles to your prayers as a hint to the usual things about taking care of Nana and her low back pain.

Despite all this, despite the sweat, the effort, the desire, look enviously at all those bastards who apparently do so many things wrong or at random, but they carry even more muscles than you could ever hope to get.

Like Salieri at their Mozart, we wonder why God has given them the skills we so desperately wanted. We wonder if they have superior muscle fiber ratios, optimal balance of testosterone / estrogen, exquisite insulin sensitivity, or perhaps possess some special, secret way to squat, deadlifts or bench.

Well, according to a new fascinating document, it is not all that, and if God has given these muscular bastards a special gift, there are many androgen receptors (ARs).

What are androgen receptors?

The AR are the cellular "ignition switches" that, activated by androgens (testosterone, dihydrotestosterone and other hormones), start the process that leads to the production of proteins – the physical building blocks of the tissues and, in this case, the muscles.

Surprisingly, the authors of this new paper found that the density of these ARs was the most important determining factor in muscle building and that the actual levels of anabolic hormones do not play an equally important role.

What have they done

Morton and his colleagues examined circulating hormones, intramuscular hormones and intramuscular hormone variables in previously trained men before and after 12 weeks of resistance training.

This means that they assessed the levels of anabolic hormones such as testosterone, free testosterone, dehydroepiandrosterone, dihydrotestosterone (DHT), insulin growth factor-1 (IGF-1), insulin-like growth factor-1 free, along with changes in 39; resistance training increase induced muscle mass.

What they found

Based on the results, men were classified as high responders (HIR) or low responders (LOR). The number of androgen receptors did not change during training, but it was always higher in the high responder group.

In fact, there was a linear relationship between the contents of the androgen receptor and the change in lean body mass (muscle). The researchers concluded the following:

"These results indicate that the contents of intramuscular androgen receptors, but neither circulating or intramuscular hormones (or the enzymes regulating their intramuscular production) have influenced skeletal muscle hypertrophy as a result of RET (resistance training). in previously trained men. "

Which means this for you

The findings of Morton's team seem to explain how hardgainers and bodybuilder champions can exist simultaneously on the same planet. Hardgainers, despite training just like their most successful counterparts, may simply be short of androgenic receptors, while behemothic lifters have a rich generosity.

In fact, the real advantage possessed by professional bodybuilders could be the fact that they are genetically endowed steroid receptors. Because they have more receptors, they can probably grow a lot, a lot, bigger than you could, even if you took an equally large steroid load.

This does not mean that having high levels of anabolic hormone in general will not help you, but the hormones can only get to the point where the contents of the muscle receptors will allow them. After all, if there is a limited number of "ignition switches", only the transcription of many proteins can occur.

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What you can do about it

There are however theoretical and proven ways to increase the density of the receptors you have or at least the sensitivity of these receptors.

Weight training by itself increases both the number and the sensitivity of androgen receptors, but I assume you are already doing the best you can through this path. Even the electric shock does the job, but no one has tried it on anything but the mice, and besides, it seems a little impractical.

Intermittent fasting works well, having shown to double the sensitivity to androgens. Likewise, studies have shown that food whey (and possibly casein), along with supplements such as forskolin, tribulus terrestris and caffeine work well.

You could combine all these dietary interventions together as follows:

  1. When you wake up take a cup or two of coffee with 1-2 capsules of Alpha Male® (contains both forksolin and tribulus terrestris).
  2. Then, 6-8 hours later, they have another 1-2 capsules of Alpha Male® with 8 ounces of water, always on an empty stomach.
  3. Serve 1 to 2 daily portions of whey or a mixture of whey and casein proteins.

However, the best results could be achieved by choosing new parents and starting over.


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source

  1. Robert W. Morton1, 2, Koji Sato3, Michael P. Gallaugher2, Sara Y. Oikawa1, 2, Paul D. McNicholas2, Satoshi Fujita4 and Stuart M. Phillips1. "The content of muscle androgen receptors but not systemic hormones is associated with skeletal muscle induced resistance training in healthy and young men." Physiol. | doi: 10.3389 / fphys.2018.01373 (full text not yet published).

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