"Coffee consumption seems to have some association with a lower risk of developing Alzheimer's disease and Parkinson's disease," explains Dr. Donald Weaver, vice president of the Krembil Brain Institute. But we wanted to explore why this is happening, which associations are involved and how they can affect age-related cognitive deterioration, "Expansion.com said.
Dr. Weaver sought help from Dr. Ross Mancini, a researcher in medical chemistry and biologist Yanfei Wang to investigate three different types of coffee: light baking, dark baking, and dark roasted caffeine.
"And caffeine-free caffeine, dark roasted and caffeine had the same potentials in our initial experimental tests, so we have noticed from the very beginning that its protective effect can not be the result of caffeine," he explains.
After that, Dr. Mancini identified a group of compounds known as phenylindans, resulting from the process of frying coffee beans. Phenylethones are unique because they are the only compounds studied in a study that prevents grouping, both beta amyloid and tau, two protein fragments common in Alzheimer's and Parkinson's disease.
"So, phenylindans are a double inhibitor. It's very interesting and we did not expect it." Weaver Weaver admits. Since coffee roasting produces larger amounts of phenylindan, darker roasting looks more protective than lightly frying. "For the first time, someone is researching how phenylalanine reacts with proteins responsible for Alzheimer's disease and Parkinson's disease," says Dr. Mancini.
The next step would be to explore the extent to which these compounds are useful and have the ability to reach the bloodstream or cross the blood-brain barrier. "
The fact that this is a natural compound with respect to synthetic is also a great advantage, admits Dr. Weaver. However, he admits that much research still needs to be taken before it can be translated into possible therapeutic options.
"This research makes epidemiological evidence and shows that there are components within the coffee that are useful for preventing cognitive decline." Interestingly, but we suggest that the coffee drug is absolutely not, "he warns.
source: Banking and business