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Low calorie diet prevents asthma symptoms, regardless of their fat and sugar

Posted 31/01/2019 04:56:05CET


Researchers from Johns Hopkins Medicine (United States) have shown in a mice study that a low calorie diet prevents asthma symptoms, regardless of the fat content and sugar in the diet. In their research, they also found that obesity caused by high-calorie diarrhea causes asthma symptoms in animals, causing lung inflammation, because the blocking drug alleviates these symptoms.

These results contribute to evidence supporting the links between obesity, inflammation and asthma and the value of anti-inflammatory drugs to treat typical obesity-related asthma symptoms. Obese people have a much greater chance of having normal weight to develop certain types of asthma or symptoms of this disease to increase.

"Previous studies have suggested that high fat or sugar content in diarrhea that leads to obesity induces inflammation and causes asthma, however, our study shows that obesity causes asthma-related asthma, regardless of diet composition, and that limiting calories to in any way can prevent or treat asthma by reducing inflammation, "explains author of the study, Vsevolod Polotsky.

In this study, published in the journal Scientific Reports, researchers have fed normal male mice with one of four children: a low-calorie diet that is a standard laboratory diet of crunchy foods without calorie restriction; a high calorie diet containing more calories and fat per gram; a high calorie diet containing more fat per gram and supplemented with additional sugar; and high-calorie, fatty foods with sugar.

In addition, separate groups of mice were fed with high-calorie diets, but their daily intake of food was limited to match the number of calories that mice eat in low calorie diet.


After eight weeks, mice with any high-calorie diet, whose diet was not limited, gained at least 7 grams more than mice with low calorie diet or mice with diets with food constraint and high calorie intake.

Then, researchers evaluated the lung function of the animals to see if mice developed asthma symptoms by measuring the congestion of pulmonary dislocation pathways when mice breathed different doses of methaquinone, a drug that causes narrowing of the airway.

When a dose of 30 milligrams per milliliter of methacholine was administered, mice with all kinds of high-calorie diets whose feeding was not restricted had narrowed airway pathways at least 6.3 times the initial value while in mice with low calorie diet or mice with By limiting foods with high intake of calories, respiratory tract decreased by 4.7 times.

The results of these tests, similar to those used to detect or diagnose asthma in humans, showed that mice with high calorie diets developed asthma symptoms and obesity.


In previous studies, Polotsky and his team showed that mice that fed high fat foods over the course of two weeks had high levels of IL-1 B (interleukin-1 beta), a protein whose presence indicates an inflammation in the body.

In their new experiments, they tried to further determine the linkages between obesity, inflammatory response, and asthma by feeding high-grade fat mice for the first time in eight weeks. They then injected a drug called anakinra mice group each day for two weeks to block the activity of IL-B protein and, hence, inflammation, preventing it from reaching the target sites. Because of its anti-inflammatory properties, anakinra is used to treat rheumatoid arthritis.

At the end of eight weeks, when they received a dose of 30 milligrams per milliliter of methacholine for the response of their respiratory tract, overdose mice with anakinrope had compressed airways 2.9 times higher than initial values, lower than 5.1-fold observed in obese mice for whom the drug was not given.

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